Epitope from Human Papillomavirus 16 E 6 Carcinomas Limit the Presentation of a CTL Antigen Processing Defects in Cervical

of April 15 , 2017 . This information is current as Epitope from Human Papillomavirus 16 E 6 Carcinomas Limit the Presentation of a CTL Antigen Processing Defects in Cervical

Epitope from Human Papillomavirus 16 E 6 Carcinomas Limit the Presentation of a CTL Antigen Processing

Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6.

Human papillomavirus (HPV) infection, particularly type 16, is causally associated with the development of cervical cancer. The E6 and E7 proteins of HPV are constitutively expressed in cervical carcinoma cells making them attractive targets for CTL-based immunotherapy. However, few studies have addressed whether cervical carcinomas can process and present HPV E6/E7-derived Ags for recognition ...

CTL Responses to a DNA Vaccine Encod-ing E7 Gene of Human Papillomavirus Type 16 from an Iranian Isolate

Background: Cervical cancer is the most prevalent tumor in developing countries and the second most frequent cancer among female population worldwide. Specific human papillomaviruses and, most notably, HPV types 16 and 18 are recognized as being caus-ally associated with cervical carcinomas. The early HPV type 16 genes, E6 and E7, di-rectly participate in the in vitro transformation of primary ...

Cytotoxic T-Cell Markers and Cytokines in Human Papillomavirus 16

Background and Aim: Cervical cancer is the fourth main cause of mortality among women, and annually about half a million new cases are detected in developed countries. Based on oncological studies, human papillomavirus (HPV) is classified into two categories: high-risk type and low-risk type, and most cases are related to the high-risk type of human papillomavirus. HPV 16 and 18 are among the m...